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Similar content being viewed by others Log in or create a free account to read this content Gain free access to this article, as well as selected content from this journal and more on nature.com or Abbreviations AEP: auditory evoked potential EEG: electroencephalograph GSH: glutathione NAC: N -acetyl-cysteine MMN: mismatch negativity NMDA: N -methyl-D-aspartate References Aydin S, Ozaras R, Uzun H, Belce A, Uslu E, Tahan V et al (2002)

Reducing exposure to toxins and pollutants, which deplete glutathione levels, by avoiding smoking, minimizing alcohol consumption, and choosing organic products when possible

IV glutathione bypasses this degradation but has a half-life of only 1030 minutes, limiting sustained effect

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Among the main findings of the research, we highlight that the supplements of greatest clinical relevance in the treatment of PCOS are characterized by being aimed at the progressive improvement of the most frequent clinical manifestations in patients, thus encompassing four important parameters to achieve an efficient result: glycemic control, dyslipidemia control, reduction of oxidative stress, and hormonal control (Figure 1)