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This tier is best suited for researchers with specific clinical goals that require the last increment of pharmacological effect

[5] Serum 25-hydroxyvitamin D, calcium, phosphate, and parathyroid hormone are re-examined at least eight weeks after each injection, and maintenance may shift to oral 1,000-2,000 IU daily once target levels (generally 30-50 ng mL ) are achieved, thereby reducing the risk of cumulative overdose while safeguarding skeletal health

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