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Due to the very low rate of creatine loss (1.7%) in the whole-body pool (creatine plus creatine phosphate), dietary supplementation with a low dose of creatine (e.g., 3 g of creatine monohydrate per day for 28 days in 76-kg men) results in a steady accumulation of creatine in skeletal muscle, and the saturation of creatine in the muscle (142 mmol/kg dry matter) occurs by day 28 (Hickner et al

Rotating injection sites between the abdomen, thigh, and upper arm prevents recurring reactions at any single location

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doi: 10.2174/1389203720666190722152415 154 SuH.HuangJ.WengS.ZhangB.ZhangT.XuY