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The GAD2 gene is located on chromosome 10p12.1 and is composed of 16 exons that generate two alternatively spliced mRNAs, both of which encode the same 585 amino acid protein (GAD 65 )

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Dysfunction of histone methyltransferases and deacetylases, especially when triggered by interferon-alpha-mediated signaling, may result in abnormal histone modifications

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