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12 (2), e1175

Less Common or More Serious Side Effects: These are rarer, especially when treatments are performed by experienced professionals, but it's important to be aware of them: Post-Inflammatory Hyperpigmentation (PIH): This is when the treated area becomes darker than the surrounding skin

S100A8/S100A9-induced increase in NADPH-oxidase activity is via S100A9 transport of the cofactor arachidonic acid to the NADPH oxidase complex, and interaction of S100A8 with cytosolic phox proteins facilitating the enzyme assembly (114)

A novel antioxidant sulfated polysaccharide from the algae Gracilaria caudata: In vitro and in vivo activities