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Reduced levels of insulin in the brain also contribute to the deposition of some really nasty substances (amyloid proteins, neurofibrillary tangles and tau proteins) and neurodegeneration

4 In recent years, however, they have been popularized as a weight-loss drug

Fumarate, one of the intermediates of the TCA cycle, is considered to be an oncometabolite that promotes cancer based on the human cases carrying heterozygous germline mutations in the fumarate hydratase ( FH ) gene