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The cardiovascular pathway In March 2024, the FDA approved Wegovy for a second indication: reducing the risk of major adverse cardiovascular events (MACE) in adults with established cardiovascular disease (CVD) and either overweight or obesity

The industry is developing new treatments to counteract this

Liraglutide was found to be protective against angiotensin II and pressure overloadinduced cardiac hypertrophy via PI3K/Akt1 and AMPK signaling in mice (43)

Regular check-ups allow for monitoring progress, addressing any side effects, and making necessary adjustments to the treatment plan

These findings are also consistent with real-world data (retrospective data from electronic health records from the TriNetX Analytics Networks) showing no increased suicidal ideation with semaglutide use compared to nonGLP-1 RAs therapies [50]