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With respect to lowering of body weight, a significant dose-dependent effect was evident with tirzepatide even when compared with the GLP-1 RAs semaglutide and dulaglutide

doi: 10.1097/shk.0b013e3182295f91 104 HuW.KongX.WangH.LiY.LuoY

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Clinical treatment strategy for MTHFR-related psychiatric disorders As MTHFR plays a critical role in one-carbon metabolism, which is composed of folate, homocysteine, vitamin B12, and methylation of DNA, mutation of specific gene locus on MTHFR and correlative enzyme activity decline will affect various of physiological events as well as some pathology states, including psychiatric disorders