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It occurs when the body produces too much melanin in an attempt to defend itself from a perceived threat

Am J Med Genet B Neuropsychiatr Genet (2008) 147B:104755.10.1002/ajmg.b.30714 41 TiwaryBK

Glia 57:12511264 Vargas MR, Pehar M, Cassina P et al (2005) Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival

The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of GPR54

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