The large amount of ROS generated upon irradiation further promotes diselenide bond cleavage and drug release
Notably, redox signaling events are significant regulators of cell death pathways, among which GSH depletion has been demonstrated to be a vital early hallmark in the progression of different cell death mechanisms [18]
Khan S, Varricchio A, Ricciardelli C, Yool AJ (2022) Invasiveness of endometrial cancer cell lines is potentiated by estradiol and blocked by a traditional medicine Guizhi fuling at clinically relevant doses
GSK3, a serine-threonine kinase prominently expressed in the brain, augments the activity of -secretase while concurrently diminishing the activity of -secretases, thereby amplifying intra- and extracellular levels of A [59, 60]
Islam T, Manna M, Reddy MK (2015) Glutathione peroxidase of Pennisetum glaucum (PgGPx) is a functional Cd2+ dependent peroxiredoxin that enhances tolerance against salinity and drought stress