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275,322 M1 macrophages promote immune activation and contribute to tissue injury by producing nitric oxide, ROS, various chemokines (CXCL2, CXCL4, and CCL5), and proinflammatory cytokines such as TNF-, IL-1, and IL-6

Maintaining a balanced diet and regular physical activity can also help manage symptoms effectively

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By demethylating H3K27, JMJD3 reverses the gene silencing effect, allowing methylated H3K4 to facilitate gene transcription [58, 59]

Sargazi-taghazi, M., Ghaznavi, H., Sheervalilou, R., Razavi, M., & Sepidarkish, M