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Li, Y., Zhao, T., Li, J., Xia, M., Li, Y., Wang, X., & Sun, P

These insights have motivated the use of partial FAO inhibitors such as trimetazidine (TMZ) and perhexiline, which improve exercise tolerance and symptoms in HF patients by reducing lipotoxic accumulation and enhancing glucose utilization (Lee et al., 2005

Frontiers in Immunology , 13

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These changes drive T cells toward senescence, a state of irreversible cell cycle arrest accompanied by the senescence-associated secretory phenotype, characterized by inappropriate activation, poorer function and enhanced secretion of proinflammatory cytokines such as IL-6, TNF-, and IFN- (Olivieri et al., 2018