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Or possibly, the combination of synthetic T1 with B cell-directed therapeutics, as the specific anti-CD20 mAbs ocrelizumab and ofatunumab or those mAbs, including natalizumab and alemtuzumab, affecting both T and B lymphocytes, may complement their ability to affect the B cell compartment

Vas de sealizacin documentadas en literatura: Activacin de telomerasa (hTERT): modelos celulares documentan induccin de actividad telomerasa y elongacin de telmeros en fibroblastos humanos en cultivo Modulacin circadiana: estudios preclnicos en roedores describen normalizacin de la secrecin de melatonina y del ritmo circadiano Regulacin gnica / cromatina: literatura experimental reporta efectos sobre la expresin gnica y la estructura de la cromatina (heterocromatina perinuclear) EVIDENCIA CIENTFICA DOCUMENTADA Khavinson VK et al., Neuro Endocrinol Lett 2003 (PMID 14523363): Epithalon en modelos de envejecimiento celular y activacin de telomerasa Anisimov VN et al., Mech Ageing Dev 2003 (PMID 12782392): Epithalon en modelos murinos de longevidad y carcinognesis Khavinson VK, Bull Exp Biol Med 2002 (PMID 12937682): efectos del tetrapptido sobre la actividad telomerasa en cultivos celulares humanos Material de investigacin nicamente

This validates the slower titration approach described in the protocol section above

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