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Recent research has shown that an endothelial-specific glycocalyx component, endomucin (EMCN), is highly expressed in the glomerular endothelium and plays a key role supporting the normal structure and function of the glomerular filtration barrier by maintaining the tight junctions, homeostasis of the glomerular endothelium, and function of podocytes (81)

Current investigations focus on biological mechanisms rather than therapeutic or cosmetic claims

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The field moved from single GLP-1 receptor agonism, to dual GIP/GLP-1 agonism, and then to adding a third receptor glucagon to capture an energy-expenditure lever on top of appetite and glucose control