The removal of this region and the multivalent presentation on a ferritin nanoparticle significantly improved DCFHPs neutralizing potency in mice relative to the use of unedited spike, since it allows the immune system to not get distracted by creating an antibody response against a region that is ultimately nonneutralizing [134]
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This novel tool, termed the Spearmans-Pearsons Decider, which expedited the processes needed to decide between a parametric or non-parametric analysis, is freely available at GitHub ( script and ReadMe in Supplementary Materials Scripts .zip file under Spearmans_Pearsons_Decider and ReadMe for Spearmans_Pearsons_Decider, respectively)