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Reduced glucose metabolism in AD may be a consequence of reduced postsynaptic neurotransmission, since depolarizing agents trigger glucose uptake in the brain and the effect is reduced in AD (1)

In MetS patients, ezetimibe with atorvastatin at 10 mg daily reduced LDL-C and improved Endothelium-dependent vasodilation (EDV) compared to 40 mg alone

606 By activating autophagy and inhibiting ferroptosis, rapamycin reduces the loss of dopamine neurons in the substantia nigra and improves behavioral symptoms in PD model mice, suggesting that the mutual regulation of ferroptosis and autophagy may provide therapeutic targets for drug therapy of PD

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By improving the profile of cytokines secreted by adipocytes and promoting the production of anti-inflammatory cytokines, it helps alleviate the inflammatory state induced by obesity [133]