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They promote lipid, protein, and DNA oxidation, forming cytotoxic products such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which compromise mitochondrial DNA and disrupt electron transport, especially at complexes I and III (Wang et al., 2024)

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This paper also highlights that patients with the R482W variant are diagnosed with diabetes at a significantly younger age compared to those with the R482Q variant (27 years vs

Extracellular glutamate levels are maintained through a balance between release and uptake in the normal brain function

InfantRisk has also emphasized that the larger concern during breastfeeding may be reduced calorie, nutrient, and fluid intake from appetite suppression, especially for a parent who is exclusively breastfeeding a newborn