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The results demonstrated a significant reduction in IRES-driven luciferase activity following SYNCRIP depletion, further supporting the idea that SYNCRIP facilitates cap-independent translation of HK2 mRNA (Figure 6F-H)

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When this happens, the gradual buildup of dysfunctional mitochondria can lead to increased inflammation, which is associated with a higher risk of chronic diseases, like cancer or dementia.8 15 So, if urolithin A can kickstart mitophagy, then it may lower your risk for chronic disease, increasing your healthspan and your lifespan

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