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Eur J Pediatr 153 , S57S61

As a complementary explanation, lactate production with metformin treatment may be due to its action on the gut microbiome (see later), by inhibition of glycerophosphate dehydrogenase, which is found in some colonic bacteria

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Here, we identify FOXO4 as a pivot in senescent cell viability." To further test what the modified protein could do, the mice both naturally ageing specimens and some that were genetically modified to age more quickly were exposed to chemotherapy drugs so that extra stress would be placed on their cells