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Both the parent and redesigned sensors responded as expected, with the new sensors demonstrating intact functionality, as evidenced by reversible changes in fluorescence corresponding to redox potential shifts ( Figure 1b and Figure S2 )

Key management considerations include: Continuing prescribed arthritis medications (disease-modifying agents, corticosteroids) as directed Monitoring for new or worsening joint symptoms that may require evaluation Maintaining adequate protein intake (generally 0.8-1.0 g/kg body weight, individualized based on age and kidney function) to preserve muscle mass during weight loss Ensuring sufficient calcium and vitamin D for bone health Reporting severe joint pain, swelling, or functional limitation promptly Patients should seek medical evaluation if they experience sudden onset of severe joint pain, joint swelling with redness or warmth, inability to bear weight, joint symptoms accompanied by fever, or persistent pain lasting more than 6 weeks