In the SURMOUNT-5 head-to-head trial ( N Engl J Med , May 2025), tirzepatide produced 20.2% average weight loss compared to 13.7% with semaglutide over 72 weeks a 47% greater relative reduction
GLP-1RAs have reliable hypoglycaemic and weight-loss effects that can intervene in obesitythe basis of type 2 diabetes pathologyand multifaceted effects on other cardiometabolic parameters, such as blood pressure and circulating lipids [21]
For confirmed B12 deficiency without neurological involvement , the standard regimen comprises 1 mg hydroxocobalamin intramuscularly three times weekly for two weeks, followed by maintenance doses every two to three months for those with irreversible causes like pernicious anaemia
Sleep deprivation increases ghrelin, the hunger hormone, by up to 15%
When Tirzepatide Is Recommended Tirzepatide may be recommended for: Patients who have plateaued on Semaglutide Individuals with metabolic resistance Patients with higher BMIs who require additional metabolic support Those seeking enhanced appetite regulation support Clinical studies have explored changes in body weight over time when medically supervised and paired with lifestyle adjustments
