The first is that semaglutide is semaglutide the molecule that produced about 15% mean weight loss in STEP 1 (Wilding et al., 2021), that reduced food-cue reward signalling in van Bloemendaal's imaging (van Bloemendaal et al., 2014), that the broader incretin literature has characterised in detail (Drucker, 2018), does not become a different molecule because of where it was synthesised
Extended Activity: Due to reduced binding to IGF-binding proteins, IGF-1 LR3 may produce more prolonged receptor engagement than equivalent amounts of native IGF-1 in experimental systems, allowing for detailed study of dosetime relationships and cumulative effects on cell populations
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N Engl J Med 389:10691084 Kosiborod MN, Petrie MC, Borlaug BA et al (2024) Semaglutide in patients with obesity-related heart failure and type 2 diabetes
Side effects after stopping The good news about discontinuation: side effects resolve