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Clinical trials show patients typically lose 510% of their starting body weight on semaglutide, and up to 1520% on tirzepatide

There is no human trial that sets a timeline, so reports are anecdotal and drawn from animal research

The results of a phase 2 trial of the triple agonist LY3437943 (Retatrutide) showed 24.2% weight loss at the highest dose (12 mg) in 48 weeks (83)

However, individuals with a known sensitivity to sulfur or those with severe sulfite oxidase deficiency should consult their healthcare provider before initiating high-dose glutathione therapy