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In OA and other inflammation-related diseases, NF-KB activation commonly leads to decreased transcription of antioxidant factors such as GPX4, NQO1, and HMOX1, thereby promoting ferroptosis (124, 125)

Int J Curr Res Physiol Pharmacol

The autophagy protein Atg12 associates with antiapoptotic Bcl-2 family members to promote mitochondrial apoptosis

Such patterns point to the potential of regional KP activity as a functional biomarker for stress-related symptom dimensions in MDD and highlight localized KP enzymes such as IDO, TDO, and kynureninase as candidate treatment targets

Unfortunately, the healing process - particularly for tendons and ligaments - can be frustratingly slow