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In turn, Ang II precipitates hypertension by promoting sodium and water retention and enhancing vasoconstriction by binding to its AT1 receptor

developmental code PNB-0408) is a synthetic small oligopeptide derived from angiotensin IV (AngIV), engineered to overcome AngIV's limitations as a research tool by adding lipophilic modifications that confer oral bioavailability and blood-brain barrier permeability

2 An important potential adverse effect is dysfunction of the bladder muscle, leading to decreased ability to empty the bladder, increased risk of UTI, and need for periodic catheterization

Pregnant or nursing women1,000-1,300 mg

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