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PNS exert antioxidant and anti-inflammatory actions similar to flavonoids, and notably they inhibit endothelial activation: in one endothelial cell study, notoginsenoside R1 and ginsenoside Rb1 from Panax blocked p38 MAPK signaling and downregulated vascular cell adhesion molecule-1 (VCAM-1) expression, thus preventing monocyte adhesion and plaque initiation (Fan et al., 2016)

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