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In a randomized, double-blind, placebo-controlled study, participants supplementing with calebin A demonstrated improved body composition markers and enhanced thermogenic activity [1]

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However, fat oxidation rates were lower than predicted from GH elevation alone, likely because continuous GH suppresses insulin sensitivity more than pulsatile patterns

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To ensure high-confidence hit selection, only compounds achieving a fit score 0.70 for each model were retained and integrated into the multi-method consensus framework used to consolidate LBVS predictions