While promising for HbA1c and weight reduction, tirzepatide exhibited a safety profile akin to GLP-1 agonists, though with increased GI issues and hypoglycemia
GlaxoSmithKline cited commercial reasons (poor market uptake compared to Trulicity and Ozempic)
It seems to act in contrast to adiponectin, which was reported to inhibit the effects of resistin [208]
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