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While iodine is essential for thyroid hormone production, excessive iodine intake can paradoxically suppress thyroid function through a mechanism known as the Wolff-Chaikoff effect

This fatigue leads to a snowball effect regarding testosterone levels

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It was suggested that hepcidin may be a vertebrate counterpart of cysteine-rich antimicrobial peptides produced in the fat body of insects due to the fact that the fat body of insects is the equivalent of the mammalian liver [156]

Preoperative radiation may also be used to shrink the tumor and improve resectability (Widemann & Italiano, 2018)