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Acknowledgments The authors thank the contributions of Asan Medical Library (University of Ulsan College of Medicine, Seoul, Republic of Korea) for providing search terms for the systematic review and Enago (www.enago.co.kr) for the English-language review

The largest psychiatric meta-analysis to date 80 randomized controlled trials, over 107,000 patients also found significant improvements in restrained eating and emotional eating with GLP-1 medications compared to placebo ( Pierret et al., JAMA Psychiatry, 2025 )

However, optimal performance was achieved at 100 mg/mL, where drug loading was about 9% and encapsulation efficiency exceeded 90%

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Updating Criteria: Payer PA rules change regularly