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Long-term use of proton pump inhibitors (omeprazole, lansoprazole) or H2-receptor antagonists (such as famotidine) reduces stomach acid, impairing B12 release from food

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In the 3-KO and WT groups, male mice aged 1214 weeks were divided into three subgroups including: saline control, AOD9604 administered at a dose of 250 g/kg/day, and hGH administered at a dose of 1 mg/kg/day

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Leading medical sources, including The BMJ and Harvards Nutrition Source, emphasize that elevated B12 levels alone do not indicate toxicity or adverse effects