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ED can be an early warning sign of cardiovascular disease or diabetes, and NICE recommends proper medical assessment including cardiovascular risk evaluation for all men presenting with erectile dysfunction

Transcription factor EB (TFEB) regulates the expression of autophagy and lysosomal genes, which is also phosphorylated and inhibited by mTORC1 to regulate autophagy indirectly [49] (Fig

3) Common pathophysiological mechanisms involving impaired SCFA production, immune-inflammatory activation, and dysregulated neuroactive metabolite metabolism