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In this context, multitargeted treatment of opioid receptors can improve the drug tolerance and safety profile [55,56], and previous studies have shown that simultaneous activation of MOR and DOR with bivalent agonist ligands delivers potent analgesia in experimental NP [57,58,59]

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However, it is important to note that normal saline contains a supraphysiological concentration of chloride (154 mmol/L), which is significantly higher than the typical plasma chloride level of 103 mmol/L

Stop if : Severe vomiting, extreme fatigue, signs of pancreatitis (severe abdominal pain)