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While the peripheral metabolic actions of GLP-1RAs are well established, accumulating evidence suggests that GLP-1RAs exert significant central nervous system (CNS) effects

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The experimental approach involves taking less than the recommended dose of a GLP-1 medication such as Ozempic, Mounjaro or Wegovy in the hope of curbing hunger pangs just enough to sustain weight loss

The proposed mechanism involves controlling glutamate release in the synaptic cleft, modulating NMDA receptor stimulation, affecting excitatory amino acid transporter (EAAT)-mediated reuptake, and maintaining the glutamate/glutamine cycle within astrocytes