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These results demonstrated that the inhibition of GCLC by BSO induced ferroptosis PANC-1 cells

When required, the samples were embedded in optimal cutting tissue medium before sectioning in a Leica CM1900 cryostat (Heidelberger, Nussloch, Germany) at a thickness of 5 m

Lipid peroxidation, ROS, and iron accumulation are common mechanisms underlying palmitic acid induction of ferroptosis in TNBC cells We next studied different hallmarks of ferroptosis, such as lipid peroxidation, mitochondrial ROS production, and iron content

Our evidence paves the way for informed guidelines and further research to mitigate anaesthesia-related risks in this patient population." The study's outcomes prompt a re-evaluation of preoperative protocols in this subset of patients, underscoring the significance of patients openly communicating their GLP-1 RA use before surgery

Database search and quantitation Raw LC-MS data were analyzed using PEAKS Online (Bioinformatics Solutions Inc.) with the Homo sapiens database from UniProt