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The five most prevalent neurodegenerative disorders (NDD) Alzheimers disease (AD), Parkinsons disease (PD), Huntingtons disease (HD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS), currently lack curative interventions (4)

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Congruently, the loss of KAT6A results in a shift in the expression of HOX genes (body segment identity), and the reduction in the expression of DLX genes (jaw and palate development) and TBX genes (heart development), among other affected genes (Voss et al, 2009, 2012