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( e ) Cells expressing empty vector (EV) or CCNE1 were treated with the IDH1 inhibitor or the PARP inhibitors veliparib (left) or niraparib (right) alone or in combination (n = 4 technical replicates representative from 2 independent experiments in each cell line)

Correlation of the in vitro biotransformation of H3B-6527 in dog and human hepatocytes with the in vivo metabolic profile of (14)C-H3B-6527 in a dog mass balance study

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This is consistent with observational studies that showed improvements in the levels of aminotransferases in patients with NASH that received Vitamin E [13]