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October 2008

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However, in a recently completed multicenter, phase III randomized controlled trial (NCT04072822), the results have shown that compared with Anakinra combined with zinc treatment, the prednisone treatment group showed higher survival and lower incidence of acute kidney injury at 90 days in severe alcoholic hepatitis (SAH) ( Current studies have demonstrated that oxidative stress and proinflammatory environment in hepatocytes activate apoptosis signal-regulating kinase 1 (ASK1), exacerbating liver inflammation, apoptosis and fibrosis ( 3.2 Promote liver regeneration There is increasing evidence that impaired liver regeneration is a key pathogenesis of AH and is closely related to disease progression and poor prognosis (Xiang et al., 2020b)