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Like JNK, the activity of ASK1 is low in nonstressed cells due to its sequestration via protein: protein interactions with GSTM1 (GSTM1: ASK1 complex), and/or thioredoxin (Trx:ASK1 complex) (Cho et al ., 2001

Glutathione, a potent endogenous antioxidant compound, is a likely mediator of these effects

2007;292:H1728H1736

Delivers high-dose Vitamin C directly into the bloodstream to support immune function at concentrations not achievable through oral intake alone