16 Baudouin-CornuP.LagnielG.KumarC.HuangM
This causes metabolic imbalances, endoplasmic reticulum stress, inflammation, and the activation of growth-inhibiting signaling pathways ( The primary antioxidant defense in cells is mediated through enzymatic and non-enzymatic systems, including factors such as glutathione (GSH), glutathione peroxidase (GPX), catalase (CAT), and superoxide dismutase (SOD) ( The Keap1-Nrf2 signaling pathway plays a crucial role in mediating the antioxidant system
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The di-tryptophan cross-link may weaken the non-covalent bonds between the SOD1 monomers, triggering enzyme unfolding, oligomerization, and aggregation (Coelho et al., 2014)
Initially, we determined whether pegvisomant treatment inhibits GH signaling in mice
