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Tirzepatide, a once-weekly glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist induced substantial weight reduction in previous placebo-controlled trials in patients with type 2 diabetes and obesity, Rohit Loomba, MD, MHSc, chief of the division of gastroenterology and hepatology at University of California, San Diego, and director of the MASLD Research Center, said at EASL Congress

On one hand, IR leads to abnormal glucose uptake and oxidation, reduced glycogen synthesis, decreased lipid metabolism inhibition, resulting in glucose metabolism imbalance

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Type 2 diabetes data In a separate Phase 2 trial, retatrutide was tested in adults with type 2 diabetes