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Pioglitazone may cause weight gain, fluid retention, and increased heart failure risk
The mechanism acts on metabolic pathways and regulates the gene expression by binding the peroxisome proliferator-activated-receptor gamma (PPAR-)
But it started off being a pharmacist in the mid-90s and that's when they started the revolution of insurance companies dictating what we are going to be having for our healthcare, for fellow Americans
For weight management, being overweight alone isnt always enough for insurance companies to cover GLP1 drugs
That said, off-label prescribing happens
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