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The mice were euthanized at 2 h after administration, and brain tissues were carefully collected, dehydrated, embedded, sectioned, and transferred to microscope slides

Clinical studies have shown that Tirzepatide can lead to greater reductions in HbA1c (a key marker of long-term blood sugar control) and more pronounced weight loss compared to semaglutide and similar medications

Science 130, 17591760

STEP 5 followed participants for 104 weeks (two years) on semaglutide 2.4 mg

Furthermore, access to GLP1-RAs is a major issue for uptake remaining relatively low despite the high efficacy of these medications (Rodriguez et al., 2025)