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Methylphenidate the active ingredient in Ritalin increases levels of dopamine and noradrenaline in the brain because it blocks the transporters responsible for removing these substances from synapses in the frontal cortex and insular lobe

Concentration and formulation quality dramatically impact both treatment effectiveness and post-discontinuation durability

National Center for Complementary and Integrative Health notes that randomized, placebo-controlled trials are the gold standard because they help determine whether apparent improvement is due to the treatment or to chance

Methods PubMed, Medline, Embase, the Cochrane Center Register of Controlled Trials for Studies, and Clinicaltrials.gov were searched from the inception to March 2024

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