Semaglutide backbone: Column: C18 column
Arg34GLP-1 (9-37) with a modification of Lys at position 26: adding N, N-diisopropylethylamine into 300mL of a mixed solution of acetonitrile and water, cooling to 0-5 , adjusting the pH to 11.5, adding 1g of Arg34GLP-1 (9-37) to form a mixture, dissolving 0.29g of the compound 1 'into 100mL of acetonitrile, dropwise adding the mixture into the mixture, reacting at 0-5 for 1 hour, adjusting the pH of the obtained reaction solution to 5.4 by using acetic acid, then adding 400mL of purified water, and centrifuging to obtain a solid compound 2', wherein the purity is only 75.83%, and a specific liquid chromatogram is shown in FIG
The problem is not carelessness
With demand continuing to surge, more pharmaceutical companies are accelerating their investments in Semaglutide production technologies
Semaglutide overdose symptoms include severe nausea, persistent vomiting, abdominal pain, and in serious cases, acute pancreatitis or severe dehydration requiring hospitalization