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The formulation originated in weight-loss clinics in the 1990s as an adjunct to calorie-restricted diets

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GHK-Cu is studied in models involving copper peptide signaling, collagen-associated pathway activity, extracellular matrix communication, angiogenesis, and tissue-response biology

Under homeostatic conditions, the deubiquitinase PSMD14 cleaves K27-linked polyubiquitin chains at K313 of IRF3, thereby preventing autophagic recognition and degradation (193)