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The model of MSA-DH was at 2.6 resolution refined to R/R free of 18/21% in space group P2 1 2 1 2 1

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Specifically, in cells, lysine is sequentially catalyzed by enzymes including AASS, ALDH7A1, AADA, DHTKD1 to generate glutaryl-CoA, which is then catalyzed by crotonyl-CoA-producing enzyme glutaryl-CoA dehydrogenase (GCDH) to produce crotonyl-CoA, that is, the precursor for the crotonylation of histones and non-histone proteins [37]

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