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This distinction is important for solubility and assay design

10.1007/s13238-019-0641-0 Protein Cell 164 WuY

[1] Chemotherapy for malignant spinal nerve sheath tumors has shown mixed results and is typically only used in patients in which surgery is not an option, or with aggressive or metastatic disease

In support of these results, a study from Druckers laboratory found that Gcgr deficiency in BAT does not impact on EE 64

Together, these observations suggest that receptor-level signaling and anti-inflammatory effects alone may be insufficient to produce functional improvement in energy-demanding tissues such as skeletal muscle and brain, where substrate turnover and mitochondrial metabolic throughput are critical determinants of tissue function