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: Individuals with severe B12 deficiency, people with difficulty absorbing B12 (due to digestive conditions), or those looking for long-lasting effects from injections

Many published protocols use serial dilutions across two to three orders of magnitude to capture dose-response behavior

Most people tolerate B12 injections very well, and side effects are usually mild and short-lived

The most extensively documented mechanism involves upregulation of vascular endothelial growth factor, known as VEGF, and the broader angiogenic program