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LPS treatment decreased complex I and complex IIdriven state-III respiration rates, whereas NR intervention normalized respiration rates (Fig 4I and J)

These functions are all part of the NEM, neuroendocrine metabolic response

Troesch B, Hoeft B, McBurney M, Eggersdorfer M, Weber P

The modified treatment-regimen estimand represents the estimated average treatment effect regardless of adherence to study intervention or initiation of prohibited weight management treatments, and assuming participants who took rescue orforglipron would not have received any additional improvement from their randomized study treatment